Clean hands can stop germs from spreading from one person to another and throughout an entire community—from your home and workplace to childcare facilities and hospitals. Wet your hands with clean, running water (warm or cold), turn off the tap, and apply soap. Use Hand Sanitizer When You Can’t Use Soap and WaterWashing hands with soap and water is the best way to get rid of germs in most situations. Sanitizers can quickly reduce the number of germs on hands in many situations. Rub the gel over all the surfaces of your hands and fingers until your hands are dry.