Pursuing Safe and Effective Anti-Viral Drugs for COVID-19Posted on April 17th, 2020 by Dr. Francis CollinsStock photo/SoumenNathRight now, the world is utterly focused on the coronavirus outbreak known as COVID-19. So let’s focus on an experimental anti-viral drug, called remdesivir, that was originally developed for the deadly Ebola virus. The commonality is that both viruses have genomes made of ribonucleic acid (RNA), which must be copied by an enzyme called RNA-dependent RNA polymerase for the virus to replicate. There were no controls, participants were not randomized, and the study lacked other key features of the more rigorously designed NIH clinical trial. [Epub ahead of publication] Structure of the RNA-dependent RNA polymerase from COVID-19 virus.