DNA Base Editing May Treat Progeria, Study in Mice ShowsPosted on January 7th, 2021 by Dr. Francis CollinsCredit: Progeria Research FoundationMy good friend Sam Berns was born with a rare genetic condition that causes rapid premature aging. That’s what makes some more recently developed DNA editing agents and approaches so important. Here’s how it works: Instead of cutting DNA as CRISPR does, base editors directly convert one DNA letter to another by enzymatically changing one DNA base to become a different base. Our three labs (Liu, Brown, and Collins) first teamed up with the Progeria Research Foundation, Peabody, MA, to obtain skin cells from kids with progeria.  Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage.