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DNA Base Editing May Treat Progeria, Study in Mice Shows
DNA Base Editing May Treat Progeria, Study in Mice ShowsPosted on January 7th, 2021 by Dr. Francis CollinsCredit: Progeria Research FoundationMy good friend Sam Berns was born with a rare genetic condition that causes rapid premature aging. That’s what makes some more recently developed DNA editing agents and approaches so important. Here’s how it works: Instead of cutting DNA as CRISPR does, base editors directly convert one DNA letter to another by enzymatically changing one DNA base to become a different base. Our three labs (Liu, Brown, and Collins) first teamed up with the Progeria Research Foundation, Peabody, MA, to obtain skin cells from kids with progeria. [4] Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage.
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