Although cancer researchers have made major strides in recent years and more people than ever are surviving longer, these advances haven’t always been accompanied by improvements in quality of life. That’s the subject of this special Cancer Health report—and it’s the next big challenge for the cancer community. Finding effective new treatments is absolutely essential—after all, there’s no quality of life if there’s no life. Making quality of life more central to cancer care means paying more attention to the experiences of people with cancer, from diagnosis through treatment and survival. Here are some key issues, with recommendations for ways the American system of cancer care has to change and tips on how individuals living with cancer—and their caregivers—can advocate for the best quality of life.