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Can Organoids Yield Answers to Fatty Liver Disease?
Can Organoids Yield Answers to Fatty Liver Disease? Takebe and his colleagues devised a special biochemical “recipe” that allowed them to grow liver organoids with sufficient cellular complexity. Now with a way to make multi-cellular liver organoids, the researchers put them to the test. Next, as highlighted in the confocal microscope image above, Takebe’s team produced organoids from iPSCs derived from children with a deadly inherited form of fatty liver disease known as Wolman disease. Ultimately, Takebe suggests it might prove useful to grow liver organoids from individual patients with fatty liver diseases, in order to identify the underlying biological causes and test the response of those patient-specific organoids to available treatments.
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